Grady, a baby monkey, is the first one whose birth will be quite revolutionary as it will be born from the frozen testicular tissue through experimental technology. After the successful freezing and defrosting the testicular tissue using an experimental methodology which could raise the expectation among the cancer patients. Professor Kyle Orwig and his team have worked for long years for this achievement.
He told, “ Well, her name’s Grady, which stands for graft-derived baby”. Professor Orwig told, “ She was born on 16 April of last year and now she is 11 months old and she plays and behaves just like every other monkey that was born in a normal way”.
Through an experimental project, the scientists of the University of Pittsburgh School of Medicine, freeze the testicular tissue after extracting a testis from five young rhesus macaques.
The animals had to undergo chemotherapy. As they initiated adolescence, the samples of tissue were defrosted by the research team and inserted back in the monkeys -along with fresh tissue from the remaining testis.
Few months after, the tissue had generated sperm, from which fetus was generated and transferred to the females. The main target was to keep safe the sperm-producing cells from the cancer treatment. During adolescence, sperm is produced while there are hormonal changes which trigger the increase of testosterone.
Treatments like chemotherapy can push to the phase of infertility. While the possibility of freezing the sperm of men before such treatment, pre-adolescent males are too young to produce it.
Father of Grady had to go through the chemotherapy at just three years old. Before his treatment, the research team extracted the testicular tissue before his maturity.
Professor Orwig told, “We used some of the sperm, that was freshly isolated to fertilise eggs and that worked, but we did not establish a pregnancy that time”.
He also added, “ So we froze the rest of the sperm and then some months later we came back, brought that sperm out and fertilised eggs and that time we were successful to establish a pregnancy and finally to produce a healthy baby”.
The entire research was published in a science journal.